| April 6, 2021 |
2021 |
/16 |
CD Marathón |
2 - 2 |
Portland Timbers |
Estadio Yankel Rosenthal |
|
— |
1 |
| April 6, 2021 |
2021 |
/16 |
Alajuelense |
0 - 1 |
Atlanta United |
Estadío Alejandro Morera Soto |
|
— |
1 |
| April 6, 2021 |
2021 |
/16 |
Arcahaie FC |
0 - 0 |
Cruz Azul |
Arcahaie, Haiti |
|
— |
1 |
| April 7, 2021 |
2021 |
/16 |
CD Olimpia |
1 - 2 |
Club América |
Estadio Tiburcio Carías Andino |
|
— |
1 |
| April 7, 2021 |
2021 |
/16 |
Philadelphia Union |
1 - 0 |
Saprissa |
Estadio Ricardo Saprissa |
|
— |
1 |
| April 7, 2021 |
2021 |
/16 |
Club León |
1 - 1 |
Toronto FC |
Estadio León |
|
— |
1 |
| April 8, 2021 |
2021 |
/16 |
Columbus Crew |
4 - 0 |
Real Estelí F.C. |
Estelí, Nicaragua |
|
— |
1 |
| April 8, 2021 |
2021 |
/16 |
Atlético Pantoja |
0 - 3 |
CF Monterrey |
Santo Domingo, Dominican Republic |
|
— |
1 |
| April 13, 2021 |
2021 |
/16 |
Alajuelense |
0 - 1 |
Atlanta United |
Atlanta, GA |
|
— |
1 |
| April 13, 2021 |
2021 |
/16 |
CD Marathón |
0 - 5 |
Portland Timbers |
Providence Park |
|
— |
1 |
| April 13, 2021 |
2021 |
/16 |
Arcahaie FC |
0 - 8 |
Cruz Azul |
Estadio Azul |
|
— |
1 |
| April 14, 2021 |
2021 |
/16 |
CD Olimpia |
1 - 0 |
Club América |
Estadio Azteca |
|
— |
1 |
| April 14, 2021 |
2021 |
/16 |
Club León |
1 - 2 |
Toronto FC |
BMO Field |
|
— |
1 |
| April 14, 2021 |
2021 |
/16 |
Philadelphia Union |
4 - 0 |
Saprissa |
Talen Energy Stadium |
|
— |
1 |
| April 15, 2021 |
2021 |
/16 |
Columbus Crew |
1 - 0 |
Real Estelí F.C. |
Crew Stadium |
|
— |
1 |
| April 15, 2021 |
2021 |
/16 |
Atlético Pantoja |
1 - 3 |
CF Monterrey |
Estadio Tecnológico |
|
— |
1 |
| April 27, 2021 |
2021 |
qf |
Atlanta United |
0 - 3 |
Philadelphia Union |
Atlanta, GA |
|
— |
1 |
| April 27, 2021 |
2021 |
qf |
Cruz Azul |
3 - 1 |
Toronto FC |
BMO Field |
|
— |
1 |
| April 28, 2021 |
2021 |
qf |
CF Monterrey |
2 - 2 |
Columbus Crew |
Crew Stadium |
|
— |
1 |
| April 28, 2021 |
2021 |
qf |
Club América |
1 - 1 |
Portland Timbers |
Providence Park |
|
— |
1 |
| May 4, 2021 |
2021 |
qf |
Cruz Azul |
1 - 0 |
Toronto FC |
Estadio Azul |
|
— |
1 |
| May 4, 2021 |
2021 |
qf |
Atlanta United |
1 - 1 |
Philadelphia Union |
Talen Energy Stadium |
|
— |
1 |
| May 5, 2021 |
2021 |
qf |
Club América |
3 - 1 |
Portland Timbers |
Estadio Azteca |
|
— |
1 |
| May 5, 2021 |
2021 |
qf |
CF Monterrey |
3 - 0 |
Columbus Crew |
Estadio Tecnológico |
|
— |
1 |
| Aug. 11, 2021 |
2021 |
sf |
CF Monterrey |
1 - 0 |
Cruz Azul |
Estadio Tecnológico |
|
— |
1 |
| Aug. 12, 2021 |
2021 |
sf |
Club América |
2 - 0 |
Philadelphia Union |
Estadio Azteca |
|
— |
1 |
| Sept. 15, 2021 |
2021 |
sf |
Club América |
2 - 0 |
Philadelphia Union |
Talen Energy Stadium |
|
— |
1 |
| Sept. 16, 2021 |
2021 |
sf |
CF Monterrey |
4 - 1 |
Cruz Azul |
Estadio Azul |
|
— |
1 |
| Oct. 28, 2021 |
2021 |
f |
CF Monterrey |
1 - 0 |
Club América |
Estadio Tecnológico |
|
— |
1 |