sources
notes
it is not known on which grounds Universidad were reinstated in the competition after their elimination in round 1
series
| Nov. 13, 1980 | CCL | 1980 | 3 | Central | C.D. Santiagueño | 1 - 3 | Pumas UNAH | Santiago de Maria, El Salvador | 1 |
| Nov. 6, 1980 | CCL | 1980 | 3 | Central | C.D. Santiagueño | 2 - 2 | Pumas UNAH | Choluteca, Honduras | 1 |