| Dec. 11, 2000 | BOL1 | 2000 | 21 | Oriente Petrolero | 1 - 0 | The Strongest | 1 | |||
| Dec. 11, 2000 | BOL1 | 2000 | 21 | Blooming | 2 - 3 | Unión Tarija | 1 | |||
| Dec. 11, 2000 | ALP1 | 2000-2001 | 13 | USMAn | 0 - 2 | WAT | 1 | |||
| Dec. 11, 2000 | ALP1 | 2000-2001 | 13 | CRB | 1 - 1 | JSMB | 1 | |||
| Dec. 11, 2000 | ALP1 | 2000-2001 | 13 | ESS | 1 - 0 | USMH | 1 | |||
| Dec. 11, 2000 | ALP1 | 2000-2001 | 13 | ASMO | 1 - 3 | USMAl | 1 | |||
| Dec. 11, 2000 | ALP1 | 2000-2001 | 13 | MCA | 1 - 0 | MCO | 1 | |||
| Dec. 11, 2000 | ALP1 | 2000-2001 | 13 | ASAM | 1 - 0 | MOC | 1 | |||
| Dec. 11, 2000 | ALP1 | 2000-2001 | 13 | CAB | 0 - 1 | USMB | 1 | |||
| Dec. 11, 2000 | ALP1 | 2000-2001 | 13 | CSC | 1 - 0 | JSK | 1 | |||
| Dec. 11, 2000 | POR1 | 2000-2001 | 14 | Beira-Mar | 0 - 2 | FC Porto | 1 |